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Recruiting dogs with bone cancer (osteosarcoma) for a new clinical trial

From: Small Animal Clinical Science

Virginia-Maryland College of Veterinary Medicine is recruiting dogs with bone cancer (osteosarcoma) for a new clinical trial


In this study, we are evaluating histotripsy, a novel treatment that can destroy tissue without radiation or heat. Enrolled dogs will undergo histotripsy treatment of their bone tumor one to three days prior to standard-of-care limb amputation. Dogs will return for recheck visits at 2 weeks, one month after completion of chemotherapy, and at 6 and 12 months after surgery.

Travel will be required to the Veterinary Teaching Hospital in Blacksburg for the histotripsy treatment and amputation surgery, and to the Animal Cancer Care and Research Center in Roanoke for the screening visit and rechecks.


  • For enrolled dogs, the study covers some expenses, including up to $2,000 of the cost of limb amputation.
  • Owners’ out of pocket costs, including initial screening to determine eligibility, are estimated at $2,000-3,500.


  • Diagnosis of appendicular osteosarcoma (bone cancer of the limb)
  • No metastatic disease
  • Limb amputation must take place as part of the study. Dogs whose limbs have already been removed are not eligible.
  • No other serious life-limiting disease
  • Owner has elected standard-of-care treatment – limb amputation and chemotherapy (Chemotherapy may be administered at another veterinary facility, but amputation must be performed at our facility)


To refer a dog for this study:  (Form must be completed by a veterinarian.)

For general questions about participation, contact Mindy Quigley at or (540) 231-1363.



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